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动脉血栓栓塞性疾病(ATED)是目前临床上发病率及病死率均很高的一类疾病,尽管疾病涉及心血管内科、神经内科、血管外科等多科室,但其根本因素是动脉内血栓形成。因此,了解和掌握动脉血栓形成过程对更好认识此类疾病有一定帮助。为了有助于读者系统地学习,我们从本期起将分别从以下几个方面分别阐述动脉血栓的形成过程。(1)ATED有哪些高危因素?它们是如何发挥作用的?(2)伴随着动脉粥样硬化斑块的形成,血管内皮细胞是如何被逐渐损伤的?(3)从动脉粥样斑块破裂到动脉内血栓形成,这一过程是如何发生的?(4)血小板在动脉血栓中的重要作用表现在哪几个方面?常用的抗血小板药物有哪几类?(5)常用的抗凝药物有哪些?有何利弊?(6)ATED常用的治疗手段有哪些?
Arterial thromboembolic disease (ATED) is currently a clinically high incidence of morbidity and mortality of a class of diseases, although the disease involved in cardiovascular medicine, neurology, vascular surgery and other departments, but the fundamental factor is intra-arterial thrombosis . Therefore, to understand and master the process of arterial thrombosis for a better understanding of such diseases have some help. In order to help readers learn systematically, we will explain the formation of arterial thrombosis separately from the following aspects from this issue. (1) What are the risk factors for ATED and how do they work? (2) How are the endothelial cells gradually damaged with the formation of atherosclerotic plaques? (3) From atherosclerotic plaque rupture To arterial thrombosis, the process is how? (4) Platelet in arterial thrombosis in an important role in several aspects? Commonly used antiplatelet drugs have what? (5) Commonly used anticoagulant drugs What are the pros and cons? (6) What are the commonly used ATED treatments?