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目的针对1例肺结核合并结核性脑膜炎患儿,检索当前最佳证据,了解激素用于治疗结核性脑膜炎的有效性、安全性和经济性,为临床实践提供参考。方法在充分评估患者情况后,提出临床问题,采用循证医学的方法检索相关资料。结果共检索出与不同问题相关的随机对照实验27篇,3篇系统评价,2篇Meta分析,9个指南。通过对检索结果进行分析。为患者制定合理的治疗方案。结果经8周治疗后,患者脑脊液基本恢复正常。结论采用循证治疗的方法,为肺结核合并结核性脑膜炎患儿确定合理的治疗目标和治疗方案,可有效提高治疗效果。
Objective To investigate the current best evidence for the treatment of tuberculosis with tuberculous meningitis in children and to find out the effectiveness, safety and economy of hormones for the treatment of tuberculous meningitis, and provide a reference for clinical practice. Methods After adequately evaluating the patient’s condition, a clinical question was raised and evidence-based medicine was used to retrieve relevant information. Results A total of 27 RCTs related to different issues were retrieved, 3 systematic reviews, 2 meta-analyzes and 9 guidelines. Through the analysis of the search results. Develop a reasonable treatment plan for the patient. Results After eight weeks of treatment, CSF returned to normal in all patients. Conclusion Evidence-based treatment for tuberculosis with tuberculous meningitis in children to determine the reasonable treatment goals and treatment options, which can effectively improve the therapeutic effect.