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目的 :探讨 p5 3、c- m yc、PCNA在大肠癌组织中的过度表达及临床意义。方法 :采用免疫组化技术检测 PCNA、c- myc、p5 3在大肠癌、癌旁组织、正常大肠黏膜及大肠腺瘤性息肉中的表达。结果 :(1 ) p5 3、 c- m yc、PCNA在大肠癌组织中的表达明显高于癌旁组织、正常黏膜及腺瘤性息肉 (P <0 .0 5 ) ;(2 )伴淋巴结转移大肠癌组织 p5 3、 c- m yc及 PCNA的阳性表达率分别为 6 0 %、 80 %和 80 % ,与无淋巴结转移者比较有显著性差异 (P <0 .0 5 )。结论 :p5 3、 c- m yc及 PCNA蛋白在大肠癌转移过程中起重要作用 ,可作为预测大肠癌预后的生物学指标 ;检测 PCNA、c- myc及 p5 3对指导临床治疗和估计预后有一定帮助
Objective: To investigate the overexpression of p5 3, c-m yc and PCNA in colorectal carcinoma and its clinical significance. Methods: The expression of PCNA, c-myc, p5 3 in colorectal carcinoma, paracancerous tissues, normal colorectal mucosa and adenoma of large intestine was detected by immunohistochemistry. Results: (1) The expressions of p5 3, c-m yc and PCNA in colorectal cancer tissues were significantly higher than those in paracancer tissues, normal mucosa and adenomatous polyps (P <0.05); (2) The positive rates of p5 3, c-m yc and PCNA in colorectal cancer tissues were 60%, 80% and 80%, respectively, which were significantly different from those without lymph node metastasis (P <0.05). CONCLUSION: The expressions of p5 3, c-m yc and PCNA play an important role in the metastasis of colorectal cancer and can be used as biological indicators to predict the prognosis of colorectal cancer. The detection of PCNA, c-myc and p5 3 in guiding the clinical treatment and prognosis Will help