论文部分内容阅读
背景:有大量的文献表明血管内皮生长因子在肿瘤的形成中起重要作用,但少有文献探讨血管内皮生长因子在鼻息肉形成中的作用。目的:探讨血管内皮生长因子及其受体在鼻腔生理及鼻息肉形成中的作用。设计:以诊断为依据设立对照的实验研究。地点和对象:实验在解放军广州军区广州总医院耳鼻咽喉科完成,对象为鼻息肉患者30例,均来自本院耳鼻喉科住院手术患者。6名志愿者为本科因非鼻息肉住院的患者。主要观察指标:鼻息肉组织和正常鼻黏膜组织血管内皮生长因子及其受体的表达。结果:血管内皮生长因子及其受体在正常鼻黏膜中呈阳性表达,在鼻息肉组织中呈强阳性表达。结论:本实验结果提示血管内皮生长因子及其受体参与正常鼻腔生理功能的调节,并参与鼻息肉的形成机制。因而推测鼻息肉术后在鼻腔应用血管内皮生长因子的拮抗剂对鼻息肉的复发有预防作用。
BACKGROUND: There is a large body of literature showing that vascular endothelial growth factor plays an important role in the formation of tumors. However, there are few studies on the role of vascular endothelial growth factor in the formation of nasal polyps. Objective: To investigate the role of vascular endothelial growth factor and its receptor in nasal physiology and nasal polyps formation. Design: An experimental study based on diagnosis. Location and Subject: The experiment was performed in Department of Otorhinolaryngology, Guangzhou General Hospital of Guangzhou Military Region, People’s Republic of China. Thirty patients with nasal polyps were admitted to our otolaryngology hospital. Six volunteers were hospitalized for non-nasal polyps. MAIN OUTCOME MEASURES: Expression of vascular endothelial growth factor and its receptor in nasal polyps and normal nasal mucosa. Results: Vascular endothelial growth factor and its receptor were positively expressed in normal nasal mucosa and strongly positive in nasal polyps. Conclusion: Our results suggest that vascular endothelial growth factor and its receptor are involved in the regulation of normal nasal physiological function and participate in the formation of nasal polyps. It is speculated that postoperative nasal polyp application of vascular endothelial growth factor antagonists on the recurrence of nasal polyps have a preventive effect.