目的　研究芦荟多糖对S180 荷瘤小鼠红细胞膜功能的影响。方法　采用荧光分光光度法、SDS 聚丙烯酰胺凝胶电泳以及唾液酸试剂盒分别测定S180 小鼠红细胞膜脂流动性、膜交联蛋白、带 3蛋白以及膜唾液酸 (SA)含量。结果　两种芦荟多糖各剂量组均能不同程度地提高S180 荷瘤小鼠降低的红细胞膜脂流动性、带 3蛋白和SA的含量 ,降低红细胞膜交联蛋白的含量 ,且中剂量均非常显著 (P <0 0 1)。结论　芦荟多糖对S180 荷瘤小鼠红细胞膜功能具有促进作用 ,这可能是芦荟多糖抗肿瘤作用的主要机制之一。 Objective To study the effect of aloe polysaccharides on red cell membrane function of S180 tumor-bearing mice. Methods Fluorescent spectrophotometry, SDS polyacrylamide gel electrophoresis and sialic acid kit were used to determine the membrane lipid fluidity, membrane cross-linked protein, band 3 protein and membrane sialic acid (SA) content in S180 mice. Results Both doses of Aloe Versicolor polysaccharides could increase the membrane fluidity of erythrocytes, the content of band 3 protein and SA, and reduce the content of cross-linked protein in erythrocyte membrane in S180 tumor-bearing mice. (P < 0 0 1). Conclusion Aloe polysaccharide can promote the function of erythrocyte membrane in S180 tumor-bearing mice, which may be one of the main mechanisms of anti-tumor effect of Aloe polysaccharide.