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目的 :探讨P5 3表达与膀胱移行细胞癌 (TCC)预后的关系。方法 :LSAB方法测定 8例正常膀胱粘膜组织及 49例TCC标本中P5 3表达 ;推断P5 3表达与TCC的关系。结果 :P5 3在正常膀胱组织中无表达 ,而在TCC中表达阳性率为 40 8% ,两组比较有显著性差异 (P <0 0 5 ) ;在T1及T2 4 期TCC中表达阳性率分别为 31 4%、64 3% ;在Ⅰ、Ⅱ、Ⅲ级TCC中分别为 13 3%、5 0 %、60 % ,显示P5 3表达阳性率随分期、分级的上升而升高 (P <0 0 5 )。随访结果表明P5 3表达阳性的TCC病人疾病进展率明显高于P5 3阴性的病人 (P<0 0 5 )。结论 :P5 3表达阳性的TCC病人预后差。
Objective: To investigate the relationship between the expression of P53 and the prognosis of bladder transitional cell carcinoma (TCC). Methods: LSAB method was used to detect the expression of P53 in 8 cases of normal bladder mucosa and 49 cases of TCC. The relationship between P5 3 expression and TCC was deduced. Results: There was no expression of P53 in normal bladder tissues, but the positive expression rate of P53 in TCC was 40.8% (P <0.05). The positive expression rates of P53 in T1 and T2 stage TCC Respectively 31 4% and 64 3%. The positive rate of P53 expression in stage Ⅰ, Ⅱ and Ⅲ TCC was 13 3%, 50% and 60% respectively (P < 0 0 5). The follow-up results showed that the rate of disease progression was significantly higher in P5 3 -positive TCC patients than in P5 3-negative patients (P <0.05). Conclusion: The prognosis of TCC patients with P5 3 positive expression is poor.