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Palmer等(1987)首次证明内皮源性舒张因子(endothelium-derived relaxing factor,EDRF)的本质是NO,随后的系列研究加深了对NO的生理功能和病理生理作用的了解。Stuehr等(1985)和Marietta等(1988)的研究显示鼠巨噬细胞内可合成NO3-,表明特定细胞内可合成NO,合成NO2-
Palmer et al. (1987) demonstrated for the first time that the intrinsic nature of endothelium-derived relaxing factor (EDRF) is NO. Subsequent studies have deepened the understanding of the physiological functions and pathophysiological effects of NO. Studies by Stuehr et al. (1985) and Marietta et al. (1988) showed that NO3- can be synthesized in murine macrophages, suggesting that NO can be synthesized in specific cells and NO2-