目的采用动脉内局部药物灌注对血管性突发性感音神经性耳聋患者进行探索性治疗。方法将41例突发性感音神经性耳聋患者随机分为两组,动脉组19例,均行全脑血管造影,将导管置于椎动脉开口,选用尿激酶30万u于30min注射完毕；常规治疗组22例,采用静脉途径给予活血、解痉药物治疗。对两组患者的疗效进行比较,疗效标准采用1997中华医学会耳鼻咽喉科学会颁布的疗效分级。结果动脉组患者痊愈9例,显效5例,有效3例,无效2例；静脉组患者痊愈4例,显效2例、有效9例,无效7例。结论动脉内局部药物灌注可能是治疗突发性感音神经性耳聋的有效治疗方法。 Objective To explore the therapeutic treatment of vascular sensorineural deafness by intra-arterial local drug infusion. Methods A total of 41 patients with sudden sensorineural deafness were randomly divided into two groups. In the arterial group, 19 patients underwent cerebrovascular angiography. The catheter was placed in the opening of the vertebral artery and 30 000 u urokinase was used for injection at 30 min. Treatment group of 22 cases, the use of intravenous route to give blood, antispasmodic drug treatment. The efficacy of the two groups of patients were compared, the standard of efficacy 1997 Chinese Medical Association otolaryngology promulgated the efficacy rating. Results In the arterial group, 9 cases were cured, 5 cases were markedly effective, 3 cases were effective and 2 cases were ineffective. In the vein group, 4 cases were cured, 2 cases markedly effective, 9 effective and 7 ineffective. Conclusion Intra-arterial local drug infusion may be an effective treatment for sudden sensorineural hearing loss.