D二聚体检测在小儿呼吸道感染性疾病诊断中的应用价值

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目的 探讨D二聚体(D-D)检测在小儿呼吸道感染性疾病诊断中的价值。方法 以200例呼吸道感染患儿为对象,以同期200例健康儿童为对照组。检测D-D,分析其诊断小儿肺部疾病的价值。根据患儿的感染类型分为上呼吸道感染组(n=65)、支气管炎组(n=42)、支气管肺炎组(n=93)。分析D-D鉴别不同感染类型的效能。结果观察组D-D水平高于对照组(P<0.05)。ROC曲线分析显示D-D诊断小儿呼吸道感染性疾病的AUC、灵敏度、特异性、最大约登指数、最佳截断点分别为0.930(95%CI:0.901~0.953)、96.50%、94.50%、0.910、0.32 mg/L。上呼吸道感染组D-D水平低于支气管炎组、支气管肺炎组P<0.05);支气管炎组D-D水平低于支气管肺炎组(P<0.05)。D-D诊断支气管炎型的AUC、灵敏度、特异性、最大约登指数、最佳截断点分别为0.727 (95%CI:0.632~0.808)、52.38%、96.92%、0.493、1.67 mg/L。D-D诊断支气管肺炎型的AUC、灵敏度、特异性、最大约登指数、最佳截断点分别为0.774(95%CI:0.710~0.830)、73.12%、72.90%、0.460、1.62 mg/L。结论 检测D-D水平有助于呼吸道感染性疾病的诊断,并可辅助呼吸道感染类型的鉴别。
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