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作者报道合成的24种氨基酸心房肽(心房肽Ⅲ)对慢性肾功能不全患者肾功能和溶质排泄的影响。 16例患者,经2小时的基值时间后,接受溶于5%右旋糖酐心房肽的静脉点滴,速度为每分钟0.005(2例)、0.0125(6例)、0.05(4例)和0.1(4例)μg/kg,连续4小时。不同剂量心房肽平均结果表明,心房肽治疗的患者与基值相比,明显增加钠和钠分数排泄(分别为每分钟130±15∶231±28μEq和3.57±0.57∶6.03±1.26%,P<0.05);亦明显增加尿氯、钙和磷的排泄。心房肽静注后2小时磷和磷分数的排泄持续增加。16例患者
The authors report the effects of a synthetic 24 amino acids atrial natriuretic peptide (atrial natriuretic peptide) on renal function and solute excretion in patients with chronic renal failure. Sixteen patients received intravenous drip in 5% dextran atrial natriuretic peptide at a rate of 0.005 (2), 0.0125 (6), 0.05 (4) and 0.1 (4) minutes per minute after a 2 hour base time Example) μg / kg for 4 hours. The atrial natriuretic effect at different doses showed that atrial natriuretic peptide significantly increased sodium and sodium excretion (130 ± 15: 231 ± 28 μEq and 3.57 ± 0.57: 6.03 ± 1.26% per minute, respectively, P < 0.05); also significantly increased urine chlorine, calcium and phosphorus excretion. Excretion of phosphorus and phosphorus fractions continued to increase 2 hours after intraventricular injection of atrial natriuretic peptide. 16 patients