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【目的】探讨α‐硫辛酸（α‐lipoic acid ，α‐LA）对糖尿病视网膜病变（DR）程度及血浆颗粒蛋白前体（PGRN）等的影响。【方法】选取 DR 患者200例，随机分为两组，每组100例，对照组采用常规治疗，观察组在对照组的基础上采用α‐LA 治疗。比较两组治疗前后的 DR 程度、PGRN 、白介素‐6（IL‐6）、血管内皮生长因子（VEGF）水平。【结果】两组治疗前单纯期 DR（NDR）、增殖期 DR （PDR）百分比比较无显著性差异（ P ＞0．05），观察组治疗后 NDR 百分比高于对照组，而 PDR 低于对照组，差异均有统计学意义（ P ＜ 0．05）；两组患者治疗前的 PGRN 、VEGF 和 IL‐6水平无统计学差异（ P ＞ 0．05），两组治疗后 PGRN 、VEGF 和 IL‐6水平均明显下降（ P ＜ 0．05），观察组下降更明显（ P ＜ 0．05）。【结论】α‐LA 可有效改善糖尿病患者的胰岛素抵抗和视网膜病变，并降低 PGRN 水平。“,”Objective] To explore the effect of α‐lipoic acid on plasma progranulin (PGRN ) in patients with diabetic retinopathy (DR) .[Methods] From January 2012 to December 2013 ,200 DR patients were re‐cruited and divided randomly into 2 groups of treatment and control (n = 100 each) .The baseline data were compared between two groups .After treatment ;DR ,glucose‐lipid metabolism ,PGRN ,vascular endothelial growth factor (VEGF) and interleukin 6 (IL‐6) were compared between two groups .[Results] Before treat‐ment ,there were nonproliferative DR (NDR ,n = 4) and proliferative DR (PDR ,n = 55) in treatment group versus NDR ( n = 46) and PDR ( n = 54) ;after treatment ,NDR (n = 67) and NDR ( n = 33) in treatment group versus NDR ( n = 60) and PDR ( n = 40) .And all differences had statistical significance ( P < 0 .05) . PGRN ,VEGF and IL‐6 had statistical inter‐group differences( P < 0 .05) .[Conclusion] α‐lipoic acid can alle‐viate insulin resistance and DR and lower the level of PGRN .