童年创伤与冲动特质对强迫症患者强迫症状的影响

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目的:探讨强迫症患者童年创伤经历与冲动特质对强迫症状的影响。方法:采用横断面研究,共纳入符合DSM-Ⅳ强迫症诊断的患者134例及与之匹配的健康对照82例,采用强迫症状分类量表(修订版)(obsessive compulsive inventory-revised,OCI-R)、Barratt冲动量表(Barratt impulsiveness scale,BIS-11)、童年创伤问卷(childhood trauma questionnaire-short form,CTQ-SF)评估两组被试强迫症状严重度、症状维度、冲动特质及童年创伤水平,耶鲁布朗强迫量表(Yale-Brown obsessive-compulsive scale,Y-BOCS)评估强迫症疾病严重度;并以强迫症状各维度得分为因变量,不同成分的冲动特质及童年创伤得分为自变量,采用多元回归分析探讨冲动特质及童年创伤对强迫症状的影响。结果:强迫症患者在无计划冲动[(26.80±4.57)分]、注意冲动[(18.96±3.51)分]、情感虐待[6(5,9)分]、躯体虐待[5(5,6)分]、情感忽视[11(9,14)分]得分高于健康对照相[分别为(24.39±4.15)分、(16.18±2.76)分、6(5,7)分、5(5,5)分、(10.00±3.42)分](n P<0.05,n P<0.01)。强迫症患者OCI-R强迫症状维度得分均显著高于健康对照(均n P<0.01)。多元回归分析显示,强迫症患者强迫排序得分受注意冲动、躯体忽视影响显著(n B=0.191,n P=0.011; n B=0.273,n P=0.005);强迫囤积的得分受情感虐待影响显著(n B=0.204,n P=0.002)。强迫观念的得分受注意冲动、情感虐待共同影响(n B=0.499,n P<0.01;n B=0.175,n P=0.008);精神中和的得分受注意冲动、躯体忽视影响显著(n B=0.365,n P<0.01;n B=0.199,n P=0.034)。n 结论:强迫症患者童年创伤及注意冲动水平对不同的强迫症状表现影响不同。“,”Objective:To explore the effect of childhood traumatic experience and impulsive traits on symptom dimensions in patients with obsessive-compulsive disorder(OCD).Methods:A cross-sectional study was performed to enroll 134 patients with obsessive-compulsive disorder diagnosed by DSM-Ⅳ and 82 healthy controls to match. The obsessive compulsive inventory-revised(OCI-R) questionnaire, and the Barratt impulsiveness scale (BIS-11) and Childhood trauma questionnaire-short form(CTQ-SF) were used to assess the symptom dimensions, impulsive traits, and childhood trauma levels of two groups.The Yale-Brown Obsessive-compulsive Scale (Y-BOCS) was used to assess severity of disease in OCD patients. The scores of each dimension of obsessive-compulsive symptoms were used as dependent variables. The impulse characteristics of different components and childhood trauma scores were independent variables. Multivariate regression analysis was used to explore the influence of impulsive traits and childhood trauma on obsessive-compulsive symptoms.Results:The scores of OCD patients in nonplanning impulsivity (26.80±4.57), attentional impulsivity(18.96±3.51), emotional abuse(6 (5, 9)), physical abuse (5(5, 6)), emotional neglect (11 (9, 14)) were higher than those in healthy controls ((24.39±4.15), (16.18±2.76), 6 (5, 7), 5 (5, 5), (10.00±3.42) respectively) (n P<0.05,n P<0.01). Each subscore of OCI-R in patients with OCD was significantly higher than those in healthy controls (alln P<0.01). Multiple regression analysis indicated that the ordering scores of obsessive-compulsive patients was affected by attentional impulsivity and physical neglect (n B=0.191, n P=0.011; n B=0.273, n P=0.005). The emotional abuse was the major impact factor of the hoarding symptom (n B=0.204, n P=0.002). The score of obsessions was affected by attentional impulsivity and emotional abuse (n B=0.499, n P<0.01;n B=0.175, n P=0.008). The scores of neutralizing were influenced by attentional impulsivity and physical neglect (n B=0.365, n P<0.01;n B=0.199, n P=0.034).n Conclusion:Childhood trauma and attentional impulsivity of OCD patients have different effects on different obsessive-compulsive symptoms.
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