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应用免疫组化方法（ＬＳＡＢ法）对５７例喉癌、下咽癌标本ｐ５３蛋白染色，进行颈淋巴结转移的相关性研究，结果发现：１）ｐ５３蛋白表达与肿瘤的临床分期有良好的对应关系，即随着临床分期的升高，ｐ５３蛋白表达率升高（Ｐ＜０．００１）；２）随肿瘤分化程度的降低，ｐ５３蛋白表达率升高（Ｐ＜０．００１）；３）ｐ５３蛋白在淋巴结转移组的表达明显高于无淋巴结转移组（Ｐ＜０．００１）。提示ｐ５３蛋白基因的突变对喉癌、下咽癌的颈淋巴转移有促进作用，因此，检测ｐ５３蛋白的表达可作为临床预测喉癌、下咽癌颈淋巴结转移趋势的重要参考指标之一。
Using immunohistochemical method (LSAB method) on 57 cases of laryngeal cancer, hypopharyngeal carcinoma specimens of p53 protein staining, correlation analysis of cervical lymph node metastasis, the results found: 1) p53 protein expression and tumor clinical stage has a good correspondence With the increase of clinical stage, the expression rate of p53 protein increased (P<0.001); 2) The expression of p53 protein increased with the decrease of tumor differentiation (P<0.001); 3) p53 The protein expression in the lymph node metastasis group was significantly higher than that in the no lymph node metastasis group (P<0.001). It is suggested that the mutation of p53 gene can promote the cervical lymph node metastasis in laryngeal cancer and hypopharyngeal cancer. Therefore, the detection of p53 protein expression can be used as one of the important reference indexes for predicting the cervical lymph node metastasis in laryngeal cancer and hypopharyngeal cancer.