Highly efficient synthesis of peptides by rational utilization of novel coupling reagents

来源 :Chinese Journal of Chemistry | 被引量 : 0次 | 上传用户:muniao090908
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
The efficiency of different peptide coupling reagents, including carbodiimides, HOBt or HOAt-derived uronium, phosphoni-um and immonium salts, halouronium, halophosphonium, 2-halopyridinium and 2-halothiazoliuim salts, was evaluated. The synthetic strategy for coded peptides andnonribosomal peptides was discussed with an emphasis on the rational selection of peptide coupling reagents. The efficiency of different peptide coupling reagents, including carbodiimides, HOBt or HOAt-derived uronium, phosphoni-um and immonium salts, halonium, halophosphonium, 2-halopyridinium and 2-halothiazoliuim salts, was evaluated. The synthetic strategy for encoding peptides and nonribosomal peptides was discussed with an emphasis on the rational selection of peptide coupling reagents.
其他文献
日产制造了一台性狂暴的机器,速度、操控乃至油耗,都令人瞠目结舌,这一切都是以不惜工本为代价。在Juke-R面前,有着东瀛战神称号的GT-R也显得黯然失色。而那些超跑的速度地位
一、中国动画电影和漫画的现状2012年6月到7月,国内有10部左右国产动画电影上映,有《赛尔号2:雷伊与迈尔斯》《猪猪侠之囧囧危机》《海鲜陆战队》《我爱灰太狼》等。就目前来
Photosensitization of TiO2 colloid by hypocrellin B (HB),a natural photodynamic pigment with extremely high photosta-bility,has been studied by surface enhance
手法治疗小儿腹泻37例闫铁青①关键词手法治疗小儿腹泻中图法分类号R72.5腹泻是小儿常见病之一,尤以两岁以下婴儿为多见。该病是因为小儿脏腑稚嫩,脾胃虚弱,再加之喂养不当,内伤乳食,外邪
以IgH和TCRγ两种基因重排为标志,通过多聚酶链反应(PCR)检测治疗终止后儿童急性淋巴细胞白血病(ALL)微小残留病(MRD).受检的18例病人中(化疗者11例,自体造血干细胞移植者7例
在莫扎特的歌剧创作中,其音乐作品多表现在旋律优美、结构严谨、古典主义色彩鲜明及超脱世俗思想强烈等几个方面。自11岁创作歌剧起,莫扎特一生共创作了17部歌剧,其中艺术成
1.概述炼油厂、石化厂、油田等在生产过程中要产生大量的高热值、易燃、易爆的生产伴生气,为了保证生产的正常运行和安全,必须将这些易爆、易燃的危险品——伴生气处理掉。
多年来,在人工智能自然语言理解领域,人们只注重对大脑功能的模仿,却忽视了人类智慧的真正源泉,外部信息。对于自然语言理解的研究,长期以来,人们一直局限于词汇、句法、语义
环孢霉素A治疗小儿难治性肾病综合征9例王晓燕高远赋夏正坤张连丰傅元凤刘光陵王兆全关键词环孢霉素A肾病综合征治疗中图法分类号R692糖皮质激素是治疗小儿肾病综合征的首选药物,然而
A new strategy for the synthesis of unsymmetrical phosphotri-esters was reported: an alcohol was converted to unsymmetrical dialkyl phosphites firstly, which t