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目的 :评价血清降钙素原 (PCT)对感染和非感染原因引起的全身炎症反应综合征(SIRS)的鉴别作用。方法 :2 2例全身感染性SIRS和 2 5例非感染性SIRS患者入选。在临床出现炎症表现 2 4h内测定血清PCT、白介素 6 (IL 6 )和C 反应蛋白 (CRP)水平。同时记录最高体温、白细胞计数、中性粒细胞比例及血小板计数。结果 :感染性SIRS组患者血清PCT(3.4± 2 .3μg/L)、IL 6 (790± 4 5 6ng/L)及最高体温 (38.7± 1.2℃ )明显高于非感染性SIRS组患者 (分别为 0 .5±1.2 μg/L ,2 6 3± 184ng/L ,38.0± 1.1℃ )。所有炎症指标中 ,PCT和IL 6鉴别感染性和非感染性SIRS的特异性 (分别为 80 %、80 % )和敏感性 (分别为 76 %、70 % )最高。结论 :PCT是鉴别感染性和非感染性SIRS较有价值的指标
PURPOSE: To evaluate the differential role of serum procalcitonin (PCT) in the diagnosis of systemic inflammatory response syndrome (SIRS) caused by infection and non-infection. Methods: Twenty-two patients with systemic infection SIRS and 25 patients with non-infectious SIRS were enrolled. Serum PCT, interleukin 6 (IL 6), and C-reactive protein (CRP) levels were measured within 24 hours of clinical signs of inflammation. At the same time record the highest temperature, white blood cell count, neutrophil ratio and platelet count. Results: Serum PCT (3.4 ± 2. 3 μg / L), IL 6 (790 ± 45 6ng / L) and maximum body temperature (38.7 ± 1.2 ℃) were significantly higher in patients with infectious SIRS than in noninfectious SIRS patients 0.5 ± 1.2 μg / L, 26 ± 184 ng / L, 38.0 ± 1.1 ° C). Of all the inflammatory markers, the specificity of PCT and IL 6 for identifying infectious and non-infectious SIRS (80%, 80%, respectively) and sensitivity (76%, 70%, respectively) was the highest. Conclusion: PCT is a more valuable marker for identifying infectious and non-infectious SIRS