1980年David,首次报告用大剂量长效黄体酮肌肉注射(250mg/次),使二例输尿管结石患者于24小时内排出结石。国内1981年以来,吴友椿和董穗生等先后报告用类似的方法治疗输尿管结石各30例和100例,对于横径<1cm、表面光滑而无炎症的输尿管结石,排石率达80～93％。有关黄体酮排输尿管结石的药理,尚未见专门的报道。 1980 David, the first report of a large dose of long-acting progesterone intramuscular injection (250mg / time), so that two patients with ureteral stones in the discharge of stones within 24 hours. Since 1981, Wu Youchun and Dong Suisheng have successively reported 30 and 100 cases of ureteral calculi in a similar way. The rate of stone discharging is 80-93% for ureteral stones with a diameter of less than 1 cm and a smooth surface without inflammation. There is no specific report on the pharmacology of progesterone and ureteral calculi.