论文部分内容阅读
目的：探讨放射损伤合并烧伤肠源性感染的特点及其复合效应。方法：采用小鼠１５％Ⅲ度烧伤、８Ｇｙ放射损伤及两伤复合的动物模型，用３Ｈ－ＴｄＲ标记大肠杆菌，喂饲小鼠，分别于伤后１～９６ｈ，９个时相点检测肝、脾、肠系膜淋巴结的ｄｐｍ值△。结果：①三类损伤后均发生了肠道细菌移居，但定植于肠道的标记菌进入组织的量和达峰值的时间不尽一致。单烧、复合伤肠道细菌移居发生早（４ｈ），单放稍晚（６ｈ），说明烧伤在早期肠道细菌移居中占主要地位；伤后６ｈ，单烧和复合伤达峰值，而单放于伤后１２ｈ细菌移居达峰值；随后细菌移居逐渐减少，到９６ｈ单烧肠道细菌移居已不明显，而此时单放和复合伤仍很严重。②单放和复合伤细菌移居的程度重，以复合伤最重，ｄｐｍ值大于单一伤，但小于两伤之和，即“１＜１＋１＜２”。结论：复合伤动物与两单伤比较，肠道细菌移居具有发生早、程度重、恢复慢的特点，防治时应予重视。
Objective: To investigate the characteristics of gonorrhea infection combined with radiotherapy and its combined effects. Methods: The animal model of 15% Ⅲ degree burn, 8Gy radiation injury combined with two injuries was used. The mice were fed with 3H-TdR labeled E.coli and the mice were sacrificed at 1-96h and 9h after injury respectively , Spleen, mesenteric lymph nodes dpm value △. Results: (1) Intestinal bacteria migrated after the three types of injury, but the amount of labeled bacteria colonized in the intestine did not reach the same level as the peak time. Single burn, combined injury intestinal bacterial migration occurred early (4h), single put slightly later (6h), indicating that burn in early intestinal bacterial migration accounted for the main position; 6h after injury, single burn and combined injury reached the peak, and single Bacterial colonization reached a peak at 12h after injury; bacterial colonization then decreased gradually, and bacterial colonization by 96h was not obvious at this time, but single and combined trauma were still very serious. Single and complex wounds migrated to a greater extent, with the heaviest combined injury, dpm value greater than a single injury, but less than the sum of two injuries, that is, “1 <1 +1 <2”. Conclusion: Compared with two single wounds, the animals with intestinal trauma have the characteristics of early, severe and slow recovery of intestinal bacteria, and should be taken into account in prevention and treatment.