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目的:探讨载脂蛋白B基因C7673T多态性与脑出血的关系。方法:采用病例原对照研究,限制性内切酶片段长度多态性技术检测载脂蛋白B基因C7673T多态性,在110例脑出血患者和101名健康对照组中的分布;比较病例组、对照组基因型、等位基因分布差异。结果:(1)脑出血组和对照组T等位基因频率分别为0.103和0.040,显著高于对照组,差异具有显著性(x2=6.263,p=0.012);(2)2组基因型分布间差异也具有统计学意义,差异具有显著性(x2=5.951,p=0.051)。结论:载脂蛋白B基因C7673T的T等位基因同脑出血相关,可能该病的易感基因。
Objective: To investigate the relationship between apolipoprotein B gene C7673T polymorphism and cerebral hemorrhage. Methods: The case-control study and restriction fragment length polymorphism (PCR-RFLP) were used to detect the C7673T polymorphism of apolipoprotein B gene in 110 patients with cerebral hemorrhage and 101 healthy controls. Control group genotypes, allele distribution differences. Results: (1) The frequencies of T allele in cerebral hemorrhage group and control group were 0.103 and 0.040, respectively, which were significantly higher than those in control group (x2 = 6.263, p = 0.012). (2) Genotype distribution There was also a significant difference between the two groups (x2 = 5.951, p = 0.051). Conclusion: The T allele of apolipoprotein B gene C7673T is associated with cerebral hemorrhage and may be a susceptible gene to the disease.