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目的 探讨穿透性大植片角膜移植治疗角膜大病灶的手术的安全性和有效性。 方法 采用 >9mm直径的角膜移植片行角膜移植术治疗角膜病 1 1例 ( 1 1只眼 ) ,并与 6～ 7mm直径角膜移植组 1 5例( 1 5眼 )进行对照。 结果 两组角膜透明率均为 1 0 0 % ;裸眼视力≥ 0 .5者大植片组有 8眼 (占72 .7% ) ,小植片组有 5眼 (占 3 3 .3 % ) ,大植片组视力恢复优于小植片组 (P <0 .0 5)。术后 1 2个月角膜散光的发生率大植片组较小植片组低 (P <0 .0 5)。大角膜植片并不增加排斥反应的治疗难度。 结论 治疗角膜病变范围较大的角膜病患者 ,采用 >9mm直径的角膜植片行角膜移植的手术方法是安全可行的。
Objective To investigate the safety and efficacy of penetrating large plantar keratoplasty in the treatment of large corneal lesions. Methods Corneal transplantation with corneal grafts> 9mm in diameter was performed in 11 cases (11 eyes) and compared with 15 cases (15 eyes) in 6 ~ 7mm diameter corneal transplantation group. Results The corneal transparency of both groups was 100%. There were 8 eyes (72.7%) in the bare-stained eyes ≥ 0.5 with 5 eyes (33.3% The visual acuity recovery of the grafting group was better than that of the mini-graft group (P <0.05). The incidence of corneal astigmatism at 12 months after operation was lower in the graft group than in the smaller graft group (P <0.05). Large corneal graft does not increase the difficulty of treatment of rejection. Conclusion The corneal graft with> 9mm diameter corneal graft is a safe and feasible method for the treatment of patients with corneal disease with larger range.