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目的:探讨两种剂量米非司酮在围绝经期功能失调性子宫出血症治疗中的疗效。方法:回顾性分析该校一、二附属医院自2010年1月～2012年1月收治的159例功能性子宫出血患者,将159例患者随机分为小剂量组即对照组78例,给予米非司酮6.5 mg/d,治疗组81例给予大剂量米非司酮12.5 mg/d。比较2组临床效果,血清促卵泡素(FSH)、雌二醇(E2)、黄体生成素(LH)、孕酮(P)、睾酮(T)水平。结果:大剂量组总有效率为98.8%,小剂量组总有效率为100.0%,两组比较差异有统计学意义(P<0.05)。治疗后小剂量组FSH、LH、E2、P水平有显著变化(P<0.05)。T水平无显著变化,P>0.05。结论:小剂量米非司酮治疗功能失调性子宫出血,止血效果好,适合临床推广。
Objective: To investigate the efficacy of two doses of mifepristone in the treatment of dysfunctional uterine bleeding in perimenopausal period. Methods: A total of 159 patients with functional uterine bleeding who were admitted to the first and second affiliated hospitals of our university from January 2010 to January 2012 were retrospectively analyzed. The 159 patients were randomly divided into low dose group (78 cases) and control group In the treatment group, 81 patients were given high dose of mifepristone 12.5 mg / d. The clinical effects, serum FSH, E2, LH, P and T were compared between the two groups. Results: The total effective rate was 98.8% in the high-dose group and 100.0% in the low-dose group. There was significant difference between the two groups (P <0.05). After treatment, the levels of FSH, LH, E2, P in small dose group had significant changes (P <0.05). T level no significant change, P> 0.05. Conclusion: The low dose of mifepristone treatment of dysfunctional uterine bleeding, hemostatic effect, suitable for clinical promotion.