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当Rh免疫作用已充分形成时,试图给Rh免疫球蛋白(RhIG)抑制免疫反应是无效的,但给予RhIG是否可抑制或逆转早期较弱的Rh免疫尚有争论。 Godel等报告初次妊娠的妇女,在妊娠末3月时,Rh免疫作用发生率为5.6%。Buchanan报导,在29个被Rh免疫的妇女中,24个产生只能被敏感的方法检出的Rh抗体,当分娩时给予RhIG后6个月,12例妇女中的11例未再查到Rh抗体。Schneider等的研究也有类似发现。他们认为给予RhIG可以抑制和逆转孕妇弱的Rh免疫作用。但据本文作者的试验,孕妇被Rh免疫有无进展与使用RhIG无关。作者对具有弱的Rh免疫现象妇女做回顾性的观察与临床研究结果对照。36例Rh免疫反应弱的妇女,
Attempts to inhibit Rh immunoglobulin immunotherapy are ineffective when Rh immunization is well established, but whether RhIG can inhibit or reverse early weaker Rh immunization remains controversial. In the first trimester of pregnancy, Godel et al. Reported a 5.6% incidence of Rh immunization in women who reported their first pregnancy. Buchanan reported that 24 out of 29 Rh immunized women produced Rh antibodies detectable only sensitively, 6 months after giving RhIG at delivery, and 11 of 12 women were not detected Rh antibody. Schneider et al’s study also found similar findings. They think giving RhIG suppresses and reverses weak Rh immunization in pregnant women. However, according to the authors of this study, the progress of pregnant women immunized with Rh has nothing to do with the use of RhIG. The authors made a retrospective review of women with weak Rh immunization against clinical findings. Thirty-six women with weak Rh immunoreactivity,