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ｓｕｌｐｅｒａｚｏｎｅ与其它抗生素对β－内酰胺酶的稳定性比较结果表明：ｓｕｌｐｅａｚｏｎｅ对１２个标准酶中的１１个酶均高度稳定，对ＴＦＭ－１、ＴＥＭ－２和ＳＨＶ－１的稳定性较头孢酮显著增强，与头孢噻肟相同。对１４个临床分离高度耐药菌所产生的β－内酰胺酶，ｓｕｌｐｅｒａｚｏｎｅ的酶稳定性也较头孢酮显著加强，其中１２个酶对ｓｕｌｐｅｒａｚｏｎｅ的相对水解率较头孢酮降低２．２～８０．２倍。对６个超广谱酶，ｓｕｌｐｅｒａｚｏｎｅ具有较好的酶稳定性，对肺炎克雷伯氏菌Ｎｏ，１０９１、４４７、８７７和异型枸橼酸杆菌Ｎｏ．８８７的酶稳定性好于头孢酮和头孢噻肟，与头孢他啶和氨曲南接近。
The stability of sulprazone and other antibiotics against β-lactamase showed that sulpeazone was highly stable against 11 of the 12 standard enzymes and more stable against TFM-1, TEM-2 and SHV-1 than cefazolin Significantly enhanced, same as cefotaxime. The stability of sulprazone to β-lactamase produced by 14 clinically isolated highly resistant bacteria was also significantly enhanced compared to cefosporone. The relative hydrolysis rate of 12 enzymes to sulperazone was 2.2 ~ 80 lower than that of cefazolin. 2 times. For six pan-spectrum enzymes, sulperazone had better enzyme stability against Klebsiella pneumoniae No. 1091, 447, 877 and C. albicans No. 887 enzyme stability than cephalosporin and cefotaxime, and ceftazidime and aztreonam close.