胰腺神经内分泌肿瘤是一类少见的肿瘤,除胰岛素瘤外,大部分在诊断时就合并远处转移。对无手术禁忌证的病人,建议手术同时切除原发灶和转移灶;对不适合手术的病人,可选择介入栓塞/化疗、射频消融,配合化疗和生长抑素类药物的治疗。综合治疗可使转移病人的5年存活率达到60%～80%,2年症状控制率达到90%。胰腺神经内分泌肿瘤肝转移行肝移植治疗还有待进一步的临床研究验证。 Pancreatic neuroendocrine tumors are a rare group of tumors, with the exception of insulinomas, which are mostly distant metastases at the time of diagnosis. For patients without surgical contraindications, surgery and resection of the primary tumor and metastasis are recommended. Patients who are not suitable for surgery may be treated with embolization / chemotherapy, radiofrequency ablation, and chemotherapy and somatostatin therapy. Comprehensive treatment of metastatic patients can make the 5-year survival rate of 60% to 80%, 2-year symptom control rate of 90%. Pancreatic neuroendocrine tumors liver transplantation for liver transplantation remains to be further clinical studies to verify.