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对27例萎缩性胃窦炎和13例萎缩性胃体炎进行胃窦G细胞计数,血清和胃窦组织胃泌素浓度测定研究,萎缩性胃窦炎初期先有胃窦G细胞数减少,随着病变加重,G细胞数进一步减少,出现血清和胃窦组织胃泌素浓度降低,且与病变程度成比例,因此临床上血清胃泌素检测可作为了解胃窦萎缩程度的一个重要指标。萎缩性胃体炎高胃泌素血症原因是胃窦G细胞的增生或/和分泌功能亢进,后者似更重要。同时伴有胃窦萎缩者,推测有十二指肠G细胞增生和分泌亢进因素参与。
Gastric sinus G cell counts were measured in 27 cases of atrophic antral gastritis and 13 cases of atrophic gastritis. Gastrin concentrations in serum and gastric antrum were measured. Gastric sinus G cells were decreased in the early stage of atrophic antral gastritis. With the worsening of the disease, the number of G cells is further reduced, serum and gastric antrum tissue gastrin concentrations decrease, and is proportional to the degree of disease. Therefore, clinical serum gastrin detection can be used as an important index to understand the degree of gastric antrum atrophy. Atrophic gastritis is a cause of hypergastrinemia due to hyperproliferation and/or secretion of G cells in the gastric antrum. The latter seems more important. Concomitant with antrum atrophy, it was speculated that duodenal G cell hyperplasia and hypersecretion factors were involved.