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乔布综合征是一种好发于幼年时期的、罕见的先天性/原发性高免疫球蛋白E综合征,属免疫缺陷综合征之一。本文主要介绍乔布综合征的发病特征、与金黄色葡萄球菌感染的关系和应用大剂量12mg/(kg·d)达托霉素+利奈唑胺,静脉给药治疗乔布综合征患者罹患的MRSA所致的急性细菌性心内膜炎以及由该细菌引起的脑内脓肿及炎症。提示了达托霉素具有剂量依赖性和安全性,在治疗免疫缺陷患者的严重炎症中,适当加大药物剂量较其他抗生素药物更为安全有效。
Jobber’s syndrome is a rare congenital / primary hyperimmune IgE syndrome that occurs in infancy, and is one of the immunodeficiency syndromes. This article mainly introduces the incidence of Qat Syndrome characteristics, the relationship with Staphylococcus aureus infection and the application of large doses of 12mg / (kg · d) daptomycin + linezolid, intravenous drug treatment of patients with Steve Jobs syndrome Acute bacterial endocarditis caused by MRSA and intracerebral abscess and inflammation caused by this bacterium. Suggesting that daptomycin is dose-dependent and safe. In the treatment of severe inflammation in immunodeficient patients, it is safer and more effective to appropriately increase the dosage of the drug than other antibiotics.