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目的探讨联合检测血清Ⅰ型胶原吡啶交联终肽(ICTP)、抗环瓜氨酸肽(CCP)抗体和类风湿因子(RF)在未分化关节炎(UA)转化为类风湿关节炎(RA)的临床预测价值。方法对192例UA患者随访12个月,采用酶联免疫吸附法检测ICTP和CCP抗体,免疫比浊法检测RF。结果单一检测指标阳性与UA转化为RA的关联强度中以CCP抗体最高,其相对危险度(RR)及95%可信区间为50.52(18.849~135.397);其次是ICTP,其RR及95%可信区间为29.77(12.253~72.348);ICTP和CCP抗体都为阳性的UA转化为RA的转化率为93.33%;ICTP、CCP抗体和RF共3项指标都为阳性的UA转化为RA的转化率为100%。结论 ICTP和CCP抗体的出现是UA患者发生RA的高危因素;ICTP、CCP抗体和RF联合检测阳性对UA向RA分化发展具有预测价值。
OBJECTIVE: To investigate the clinical value of combined detection of ICTP, CCP antibody and rheumatoid factor (RF) in the transformation of undifferentiated arthritis (UA) into rheumatoid arthritis (RA ) Clinical predictive value. Methods A total of 192 patients with UA were followed up for 12 months. ICTP and CCP antibodies were detected by enzyme - linked immunosorbent assay (ELISA) and RF by immunoturbidimetry. Results Among the correlations between the positive detection of UA and the conversion of RA to RA, the highest level of anti-CCP antibody was found. The relative risk (RR) and 95% confidence interval were 50.52 (18.849-135.397), followed by ICTP. The RR and 95% The interval of signal transduction was 29.77 (12.253 ~ 72.348). The conversion rate of UA to RA with positive ICTP and CCP was 93.33%. The conversion from UA to RA with positive ICTP, CCP and RF It is 100%. Conclusion The emergence of ICTP and CCP antibodies is a risk factor for the development of RA in UA patients. Positive detection of ICTP, CCP antibody and RF may have predictive value for the differentiation of UA into RA.