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利用大鼠离体皮肤，对二氢埃托啡（ＤＨＥ）的体外透皮进行了研究，结果当ｐＨ为５，３，７，９时在其它条件相同的情况下，ＤＨＥ的透过速率按顺序增加；ＤＨＥ浓度对透皮速率影响较为复杂，当ｐＨ为７和９时，ＤＨＥ浓度分别为２０，４０，８０μｇ／ｍｌ时，透皮速率常数与浓度无关，当ｐＨ为３和５时，透皮速率常数与浓度有一定的相关性；一些透皮促渗剂的影响为：５０％乙醇无促进作用，１０％１，２．丙二醇促进作用甚微，３％氮酮使ＤＨＥ透皮速率提高到１．９５倍，３％薄荷醇使ＤＨＥ透皮速率提高到４．８６倍。
In vitro transdermal application of dihydroetorphine (DHE) was studied using isolated rat skin. As a result, the permeation rates of DHE at pH 5, 3, 7 and 9 were the same for all other conditions The results showed that the DHE concentration had a more significant effect on the transdermal rate. When the pH was 7 and 9, the transdermal rate constants had no relation with the concentration when the DHE concentrations were 20, 40 and 80μg / ml, respectively. When the pH was 3 and 5, Transdermal rate constants and concentrations have some relevance; some transdermal enhancers affect: 50% ethanol without promoting effect, 10% 1,2. Propanediol promoted little effect, 3% Azone increased DHE transdermal rate to 1.95 times, 3% menthol increased DHE transdermal rate to 4.86 times.