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甲腈咪胍(cimetidine)是经典的 H_2-拮抗药,而后引进临床的有雷尼替丁(Ranitidine)及奥米替丁(Oxmetidine)。后二个药对 H_2-受体的拮抗作用更强,副作用及相互作用亦有所不同,目前固内以甲腈咪胍为最常用。一、药物的相互作用自从甲腈咪胍在临床应用以来,药物相互作用的报道甚多。药物在肝内代谢分为由细胞色素 P_(450)进行的第1期药物代谢及结合反应的第2期药物代谢。甲腈咪胍可与细
Cimetidine is a classic H 2 -targeting drug, followed by the introduction of ranitidine and oxmetidine clinically. The latter two drugs have a stronger antagonistic effect on H 2 -receptors and have different side effects and interactions. At present, cimetidine is the most commonly used in the solid. First, the drug interactions Since cimetidine in clinical applications, drug interactions have been reported. Drug metabolism in the liver is divided into the first phase by the cytochrome P_ (450) drug metabolism and the second phase of drug metabolism. Cimetidine can be fine with