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FBXW7基因编码F-box蛋白家族的一员,广泛存在于人体各组织细胞中,包括FBXW7α、FBXW7β、FBXW7γ等三个不同的亚型,是Skp1-Cul1-F-box类泛素连接酶E3复合体中能够特异性识别底物的关键因子。在细胞周期进程、细胞增殖、细胞凋亡中起重要调控作用。近期有研究证实,FBXW7在血管内皮细胞迁移,发生炎症和内皮屏障完整性,血管的生成以及形成动脉粥样硬化斑块等方面具有重要作用。深入了解FBXW7及其在冠心痛中的作用将为治疗提供新的思路和策略。
FBXW7 gene encodes a member of the F-box protein family, which is widely found in various tissues of human body, including three different subtypes of FBXW7α, FBXW7β and FBXW7γ, and is a member of the Skp1-Cul1-F-box ubiquitin ligase E3 complex Body can specifically identify the key factor of the substrate. In the cell cycle progression, cell proliferation, apoptosis plays an important regulatory role. Recent studies have confirmed that FBXW7 plays an important role in vascular endothelial cell migration, inflammation and endothelial barrier integrity, angiogenesis and the formation of atherosclerotic plaque. In-depth understanding of FBXW7 and its role in coronary crown pain will provide new insights and strategies for treatment.