A first total synthesis of isoliquiritin was accomplished starting from p-hydroxy- benzaldehyde and 2,4-dihydroxyacetylphenone. The key step is condensation reaction. In synthetic process need not protect the hydroxy group of reacting substance. A first total synthesis of isoliquiritin was accomplished starting from p-hydroxy-benzaldehyde and 2,4-dihydroxyacetylphenone. The key step is condensation reaction.