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片形吸虫病(fascioliasis)是由片形吸虫(Fasciola spp.),包括肝片形吸虫和大片形吸虫感染引起的人畜共患寄生虫病。牛羊等经济动物的感染可引起产奶、产肉量降低,劳作能力下降,造成巨大的经济损失:人体片形吸虫病可导致感染者严重的肝、胆病理损伤。片形吸虫病的临床表现和影像学诊断与其它肝胆疾病类似,极易被误诊。目前粪便虫卵病原学检测是最常用的片形吸虫病诊断方法,但存在漏诊、需要专业的镜检人员操作等问题。免疫学诊断技术因具有较高的特异性、敏感性且操作简单易行,近年来已成为片形吸虫病最常用的辅助诊断手段。该文主要综述了片形吸虫病免疫诊断抗原的研究进展。
Fascioliasis is a zoonotic parasitic disease caused by the infection of Fasciola spp., Including Fasciola hepatica and Fasciola. Infected animals and animals such as cattle and sheep can cause milk production, reduce the amount of meat production, work ability declines, resulting in huge economic losses: human form of fluke disease can cause severe infection of liver and gallbladder pathology. The clinical manifestation and imaging diagnosis of Fasciola comosa is similar to other hepatobiliary diseases and can easily be misdiagnosed. At present, stool egg disease etiological testing is the most commonly used method of diagnosis of flaccid schistosomiasis, but there is a problem of missed diagnosis and professional operation of the mirror examiner. Due to its high specificity, sensitivity and easy operation, immunological diagnostic techniques have become the most commonly used diagnostic aid for the diagnosis of Fasciola fluviae in recent years. This article mainly reviewed the research progress of immunodiagnosis antigen of Fasciola.