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目的分析小儿病毒性脑炎与血清IL-1、TNF-α水平的相关性。方法选取60例病毒性脑炎患儿,进行综合治疗并应用纳洛酮联合更昔洛韦治疗,分别检测患儿急性期与治疗后血清IL-1、TNF-α的水平,同时选取60例健康者作为对照组,进行比较分析。结果重症组及轻症组病毒性脑炎患儿急性期血清IL-1、TNF-α水平均显著高于对照组,且重症组明显高于轻症组,差异均有统计学意义(P<0.05)。治疗后重症组及轻症组患儿血清IL-1、TNF-α水平均较治疗前显著降低,且治疗后重症组患儿血清IL-1、TNF-α水平仍高于轻症组患儿,差异均有统计学意义(P<0.05)。结论病毒性脑炎患儿血清中IL-1、TNF-α水平均显著提高,其水平能够反应疾病的发生、发展及治疗情况。
Objective To analyze the correlation between viral encephalitis in children and serum levels of IL-1 and TNF-α. Methods Sixty children with viral encephalitis were selected and treated with naloxone combined with ganciclovir. The levels of IL-1 and TNF-α in serum of children with acute encephalitis and after treatment were detected respectively. Sixty patients Healthy people as a control group, for comparative analysis. Results Serum levels of IL-1 and TNF-α in children with severe etiology and mild encephalitis were significantly higher than those in control group, and were significantly higher in severe etiology group than in mild etiology group (P < 0.05). Serum levels of IL-1 and TNF-α in severe and mild group after treatment were significantly lower than those before treatment, and serum levels of IL-1 and TNF-α in severe group were still higher than those in mild group , The differences were statistically significant (P <0.05). Conclusion Serum levels of IL-1 and TNF-α in children with viral encephalitis are significantly increased, and their levels can reflect the occurrence, development and treatment of the disease.