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目的:观察来氟米特和雷公藤多甙联合治疗重症类风湿关节炎3个月后的疗效及不良反应。方法:将46例重症类风湿关节炎随机分为治疗组和对照组各23例,治疗组接受国产来氟米特和雷公藤甙联合治疗,对照组接受甲氨喋呤和柳氮磺胺吡啶联合治疗,总疗程均为三个月。观察两组治疗前后各项临床和实验室指标的变化,并比较不良反应发生率。结果:治疗组与对照组比较各项临床和实验室指标的变化量及总有效率均无显著性差异,不良反应发生率亦无显著性差异。结论:国产来氟米特联合雷公藤多甙治疗重症类风湿关节炎安全有效。
Objective: To observe the efficacy and side effects of leflunomide and tripterygium glycosides in treating rheumatoid arthritis after 3 months. Methods: 46 cases of severe rheumatoid arthritis were randomly divided into treatment group and control group of 23 cases, the treatment group received domestic leflunomide and tripterygium glycosides combined treatment, the control group received methotrexate and sulfasalazine combined Treatment, the total course of treatment is three months. The changes of clinical and laboratory indexes before and after treatment in both groups were observed, and the incidence of adverse reactions was compared. Results: There was no significant difference between the treatment group and the control group in the changes of the clinical and laboratory indexes and the total effective rate. There was no significant difference in the incidence of adverse reactions between the treatment group and the control group. Conclusion: Leflunomide combined with Tripterygium glycosides for the treatment of severe rheumatoid arthritis is safe and effective.