克罗恩病是一种病因尚不明确的慢性肠道炎性肉芽肿性疾病。偶有口腔组织受累,损害主要见于唇、颊黏膜及牙龈。本文报道一例有口腔病变的克罗恩病,24岁,男性,口腔溃疡不愈半年,伴有2月腹痛史。口腔溃疡活检病理诊断为克罗恩病。临床检查发现除了消化道病损、口腔溃疡、上颌窦黏膜增厚外,出现了罕见的广泛牙槽骨吸收,而患者无牙周病及激素用药史,这一特点在以前的文献中未见报道。 Crohn’s disease is a chronic intestinal inflammatory granulomatous disease whose cause is not yet known. Occasional oral tissue involvement, damage mainly seen in the lips, buccal mucosa and gums. This article reports a case of Crohn’s disease with oral lesions, 24 years old, male, oral ulcers unhealed for six months, with a history of abdominal pain in February. Oral ulcer biopsy pathology diagnosis of Crohn’s disease. Clinical examination found that in addition to gastrointestinal lesions, oral ulcers, maxillary sinus mucosa thickening, the emergence of a rare wide range of alveolar bone resorption, and patients without periodontal disease and hormone medication history, this feature has not been seen in the previous literature Reported.