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急性心肌梗死后再灌注损伤的临床意义急性ST段抬高型心肌梗死(STEMI)是严重威胁生命的冠心病急症,通过溶栓或急诊介入手术恢复闭塞冠状动脉(冠脉)血流的再灌注疗法已经显著降低死亡率,但患者依然可能因为心肌大量丢失而出现心力衰竭和心血管不良事件。接受再灌注治疗的STEMI患者,其最终的心肌损伤程度取决于缺血面积、缺血时间和心肌水平的血流恢复,后者被定义为微循环水平的再灌注,是决定再灌注实际疗效和预后的关键因素之一~([1])。
Clinical Significance of Reperfusion Injury after Acute Myocardial Infarction Acute ST-segment elevation myocardial infarction (STEMI) is a serious, life-threatening coronary heart disease that reperfusion of occluded coronary artery (coronary) blood flow is resumed by thrombolysis or emergency intervention Therapy has significantly reduced mortality, but patients still may experience heart failure and cardiovascular adverse events because of a heavy loss of myocardium. The final extent of myocardial damage in STEMI-treated STEMI patients is dependent on the area of ischemia, blood flow at the time of ischemia, and the level of myocardial recovery, the latter being defined as the level of microcirculation reperfusion that determines the actual effect of reperfusion One of the key prognostic factors ~ ([1]).