甲苯咪唑服用剂量大,且在一般溶剂中溶解度差,利用它在三氟醋酸(TFA)中’HN-MR在4.10ppm呈尖锐单峰(-OCH_3质子),不受其它质子共振峰干扰,用苯佐卡因作内标,在TFA中在4.57ppm有清晰四重峰(-CH_2—质子)。将两者积分值相比,得出甲苯咪唑含量,与CISP中非水滴定法(须用D_1差示电位法指示终点)相比,准确度和精密度均无显著差异,回收率 99.29±0.62％。称取含20～130mg甲苯咪唑样品置于 Mebendazole was administered in large doses and poorly soluble in common solvents. With its use in trifluoroacetic acid (TFA), HN-MR showed a sharp single peak (-OCH_3 proton) at 4.10 ppm and was not disturbed by other proton resonances. Benzocaine as an internal standard has a clear quartet (-CH2-proton) at 4.57 ppm in TFA. Compared with the integral value of the two, we got the content of mebendazole. Compared with the non-aqueous titration in CISP (the end point must be indicated by D_1 differential potential method), the accuracy and precision were not significantly different, the recovery rate was 99.29 ± 0.62% . Weigh 20 ~ 130mg mebendazole samples placed