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选择体外培养人脐静脉内皮细胞(HU-VEC)为研究对象,研究了不同浓度NO供体 SIN-1(3-morpholinosydnonimine)对内皮细胞的作用以及SOD、CAT对内皮细胞的保护作用。结果提示:高浓度SIN-1可严重损伤内皮细胞;SOD、CAT能协同减轻NO对内皮细胞的损伤,说明ONOO~-的产生可能是NO损伤内皮细胞的重要机制。
In vitro culture of human umbilical vein endothelial cells (HU-VEC) as the research object, the effects of different concentrations of NO donor SIN-1 (3-morpholinosydnonimine) on endothelial cells and the protective effect of SOD and CAT on endothelial cells were studied. The results suggest that high concentrations of SIN-1 can seriously damage endothelial cells; SOD, CAT can synergistically reduce the damage of NO to endothelial cells, indicating that ONOO ~ - may be an important mechanism of NO injury of endothelial cells.