Ⅱ、Ⅲ期乳腺癌和多个腋窝淋巴结阳性病人 ,如果仅行局部区域治疗 ,5年复发率约为 80 %。多个随机试验表明 ,辅助化疗和激素疗法可减少 1 5%～ 3 5%的死亡。然而 ,在诊断时伴微小转移的绝大多数病人仍会复发甚至死亡。因此 ,需要改进系统治疗 ,增加高危乳腺癌病人的治愈率。未 Stage II and III breast cancer and multiple axillary lymph node positive patients, if only local regional treatment, the 5-year recurrence rate is about 80%. Multiple randomized trials have shown that adjuvant chemotherapy and hormone therapy can reduce deaths by 15% to 35%. However, the vast majority of patients with micrometastasis at diagnosis still relapse or even die. Therefore, there is a need to improve systemic treatment and increase the cure rate of high-risk breast cancer patients. not