二尖瓣装置在解剖结构或功能上的异常造成左心室收缩时左心室内血液部分反流到左心房即称为二尖瓣关闭不全(MR)。二尖瓣装置由二尖瓣环、瓣叶、腱索及其所连接的乳头肌等所组成。MR动物模型的创建对于我们进一步研究MR的发病机制、进行性损害机制及治疗效果有着重要的意义。本文综述了目前国内外MR动物模型的建立及其手术治疗方法。 Mitral valve device in the anatomical structure or function of the abnormalities caused by left ventricular systolic left ventricular blood flow to the left atrium partially known as mitral regurgitation (MR). Mitral valve device consists of mitral annulus, valve leaflets, tendons and connected to the papillary muscles and other components. The establishment of animal models of MR is of great significance for further study of the pathogenesis of MR, the mechanism of progressive damage and the therapeutic effect. This review summarizes the current domestic and foreign animal model of MR and its surgical treatment.