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免疫反应在各种疾病的发生、发展以及转归中发挥着重要作用，T免疫球蛋白及黏蛋白分子3（Tim－3）是近年来新发现的一种免疫细胞1型细胞表面分子，与配体 Galectin－9（Gal－9）结合后对机体的免疫细胞尤其是辅助性T细胞1（ Th1）的定位、分化趋势及分泌功能等产生影响，从而改变机体正常的免疫功能，对相关疾病的发生起到延缓或促进作用。该文总结了 Tim－3／Gal－9通路在自身免疫性疾病、移植免疫、抗感染免疫以及肿瘤免疫中的作用。“,”The immune response plays an important role in the occurrence,development and outcome of various diseases.The T-immunoglobulin and mucin-3(Tim-3) is a newly found surface molecule of immune cell type-1 in recent years.It can alter the normal immune function of body,delay or promote the occurrence of related diseases due to its combination with a widely distributive ligand Galectin-9(Gal-9),influencing the orientation,the differentiation tendency and the secretion function of the immune cells,especially Th1 cell. Here is to make a review of the impact of Tim-3/Gal-9 on autoimmune diseases,transplantation immunity, anti-infection immunity and tumor immunity.