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应用ＰＣＲ／ＳＳＯ方法对５１例经肾穿刺证实ＩｇＡ 肾病患者和９６名健康对照人员进行了ＨＬＡ－ＤＱＢ１等位基因分型。结果显示ＩｇＡＮ 患者组中ＤＱＢ１０３０２基因频率明显高于正常对照组（Ｐｃ ＜ ０．００１，ＲＲ为８．２０）；ＩｇＡＮ患者组中ＤＲ４、ＤＱＢ１０３０２均为阳性的表型频率也明显高于对照组（Ｐ＜ ０．００１，ＲＲ为６．４３），而ＤＲ４阳性、ＤＱＢ１０３０２阴性的表型频率在两组中无差异。推测ＤＱＢ１０３０２等位基因可能与上海汉族ＩｇＡＮ的发病有一定的关联。
HLA-DQB1 alleles were genotyped by PCR / SSO in 51 patients with IgA nephropathy confirmed by renal biopsy and 96 healthy controls. The results showed that the frequency of DQB1 * 0302 gene in IgAN patients was significantly higher than that in normal controls (P <0.001, RR was 8.20). The frequencies of DR4 and DQB1 * 302 in patients with IgAN were also significantly higher In the control group (P <0.001, RR was 6.43), while the DR4 positive, DQB1 * 0302 negative phenotype frequency in the two groups no difference. It is speculated that DQB1 * 0302 allele may be associated with the incidence of IgAN in Shanghai Han population.