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目的:探讨急性有机磷中毒患者(AOPP)血常规动态变化特点及长托宁的干预效果观察。方法:对我院34例急性有机磷中毒患者采用长托宁治疗,分析了入院第1,3,5,7,9天患者血液的各种指标动态变化趋势。结果:长托宁治疗后患者的血液指标均得到明显改善,治疗前后血液指标的差异有统计学意义(P<0.05);不同中毒程度各种血液指标的差异有统计学意义(P<0.05),其中除了白细胞数量(WBC)和中性粒细胞比例(N)在重度中毒患者中最高,而其他血液指标值在重度中毒患者中最低;对患者有无并发症的分析显示:两者之间除了平均红细胞体积(MCV)和血小板比积(PCT)的差异没有统计学意义(P>0.05)其他各种血液指标的差异均有统计学意义(P<0.05)。结论:长托宁对急性有机磷中毒的治疗效果好,不同中毒程度以及患者并发症的有无对血液指标有明显的影响,为急性有机磷中毒的病理变化提供理论基础,有助于临床病情的观察以及预后的判断。
Objective: To investigate the dynamic changes of blood routine in patients with acute organophosphate poisoning (AOPP) and the effect of penehyclidine intervention. Methods: Thirty-four patients with acute organophosphate poisoning in our hospital were treated with penehyclidine hydrochloride. The trends of various indexes of blood in patients on the 1st, 3rd, 5th, 7th and 9th days after admission were analyzed. Results: The blood parameters of patients treated with penehyclidine were significantly improved (P <0.05), and the differences of blood indexes among different degrees of poisoning were statistically significant (P0.05) , With the exception of WBC and neutrophil ratio (N), which were the highest among severe poisoning patients, while the others were the lowest among those with severe poisoning. The analysis of patients with or without complications showed that between the two There were no significant differences in mean blood cell volume (MCV) and thrombocytopenia (PCT) (P> 0.05) between other blood parameters (P <0.05). CONCLUSION: Penehyclidine has a good therapeutic effect on acute organophosphate poisoning, different poisoning degree and the presence or absence of complication of patients have significant effect on blood indexes, and provide the theoretical basis for the pathological changes of acute organophosphate poisoning, and contribute to the clinical condition Observation and prognosis.