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自从在一位误诊为神经性厌食的男性病人中发现有垂体损害以来,神经性厌食患者被怀疑有下丘脑—垂体障碍。已证实神经性厌食病人有特殊的神经内分泌功能异常,但未显示有垂体功能障碍或全垂体功能减退的基本特征。闭经是神经性厌食患者的重要指征。根据下丘脑—垂体—卵巢轴的功能进行广泛研究发现,除促黄体和促卵泡激素异常外还报告有生长激素(GH)和促甲状腺激素(TSH)
Patients with anorexia nervosa have been suspected of having hypothalamic-pituitary disorders since pituitary damage was found in a male patient misdiagnosed as anorexia nervosa. It has been demonstrated that patients with anorexia nervosa have specific neuroendocrine dysfunction but no basic features of pituitary dysfunction or pituitary dysfunction. Amenorrhea is an important indicator of anorexia nervosa. Extensive studies based on the hypothalamic-pituitary-ovarian axis function have found that growth hormone (GH) and thyrotropin (TSH) are reported in addition to luteal and follicle stimulating hormone abnormalities