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目的通过对痛风合并糖尿病患者及痛风不合并糖尿病患者的血尿酸、血脂等指标进行对比分析,探讨痛风合并糖尿病与相关指标的关系。方法收集2010年5月至2013年1月我院门诊或住院确诊的痛风患者共215例,分为痛风血糖正常组(177例,A组)和痛风合并糖尿病组(57例,B组),分别搜集其临床资料及检测肝肾功能、血脂、血糖水平并进行统计学分析。结果 B组年龄、动脉收缩压及舒张压、血尿酸水平、总胆固醇、极低密度脂蛋白明显高于A组(P<0.05或0.01),高密度脂蛋白低于A组[(1.00±0.32)mmol/L vs.(1.13±0.37)mmol/L,P<0.05];Spearman相关分析发现,血尿酸水平与年龄(r=0.125,P<0.05)、体重指数(r=0.218,P<0.01)、总胆固醇(r=0.200,P<0.01)、极低密度脂蛋白(r=0.274,P<0.01)、血糖(r=0.162,P<0.01)呈正相关,与高密度脂蛋白呈负相关(r=0.186,P<0.05);而血糖水平与年龄(r=0.155,P<0.05)、体重指数(r=0.160,P<0.01)、腰臀比(r=0.203,P<0.01)、动脉收缩压及动脉舒张压(r=0.204,P<0.01;r=0.157,P<0.05)、总胆固醇(r=0.283,P<0.01)、甘油三酯(r=0.234,P<0.01)、极低密度脂蛋白(r=0.299,P<0.01)、载脂蛋白B100(r=0.170,P<0.01)、血尿酸(r=0.162,P<0.01)、胱抑素C(r=0.200,P<0.05)呈正相关,与高密度脂蛋白(r=-0.136,P<0.05)呈负相关。结论痛风合并糖尿病者较痛风不合并糖尿病者血脂代谢更紊乱,腹型肥胖及血压升高更明显,增龄,肥胖,总胆固醇增高、高极低密度脂蛋白和低高密度脂蛋白血症的痛风患者可能是并发糖尿病的危险因素。
Objective To compare and analyze the indexes of serum uric acid, blood lipid and other indicators of gout with diabetes mellitus and patients with gout without diabetes to explore the relationship between gout and diabetes and related indicators. Methods A total of 215 patients with gout diagnosed in our hospital from May 2010 to January 2013 were divided into normal group (177 cases, group A) and gout combined with diabetes group (57 cases, group B) Collect their clinical data and detect liver and kidney function, blood lipids, blood glucose levels and statistical analysis. Results The age, arterial systolic pressure, diastolic blood pressure, serum uric acid level, total cholesterol, and very low density lipoprotein in group B were significantly higher than those in group A (P <0.05 or 0.01) and high density lipoprotein was lower than that in group A [(1.00 ± 0.32 (r = 0.125, P <0.05), body mass index (r = 0.218, P <0.01), Spearman correlation analysis showed that serum uric acid levels were significantly correlated with age, ), Total cholesterol (r = 0.200, P <0.01), very low density lipoprotein (r = 0.274, P <0.01) and blood glucose the body mass index (r = 0.160, P <0.01), WHR (r = 0.203, P <0.05) Arterial systolic pressure and diastolic arterial pressure (r = 0.204, P <0.01; r = 0.157, P <0.05) and total cholesterol (r = 0.283, (R = 0.162, P <0.01), cystatin C (r = 0.992, P <0.01), high density lipoprotein (r = P <0.05), but negatively correlated with high density lipoprotein (r = -0.136, P <0.05). Conclusions Gout with diabetes is more disordered blood lipid metabolism, abdominal obesity and blood pressure are more obvious than those with gout without diabetes, and age, obesity, total cholesterol, high-density low density lipoprotein and low-density lipoproteinemia Gout patients may be a risk factor for concurrent diabetes.