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寄生虫免疫学发展缓慢的重要原因之一,在于寄生虫抗原的复杂性。它给实验研究工作带来重重困难,影响对保护性免疫机制的了解,而且在免疫诊断领域,也因没有限定抗原而不断遭受挫折。Kohler和Milstein(1975)首创的杂交瘤技术,为寄生虫免疫学研究提供了非常有用的工具。迄今,国内外已有廿余种(亚种)寄生虫应用了杂交瘤技术进行研究。如原虫方面有恶性疟原虫、间日疟原虫、诺氏疟原虫(Plasmodium knowlesi)、约氏疟原虫(P.yoelli)、伯氏疟原虫(P.berghei)、夏氏鼠疟原虫(P.chabaudi)、鸡疟原虫(P.gollinaceum)、杜氏利什曼原虫、热带利
One of the important reasons for the slow development of parasite immunology lies in the complexity of the parasite’s antigen. It brings with it many difficulties in experimental research, affecting the understanding of the protective immune machinery and in the field of immunodiagnosis, it continues to suffer setbacks due to the lack of defined antigens. The hybridoma technology pioneered by Kohler and Milstein (1975) provides a very useful tool for parasite immunology research. To date, more than 20 species (subspecies) of parasites have been studied using hybridoma technology at home and abroad. In the case of protozoa there are Plasmodium falciparum, Plasmodium vivax, Plasmodium knowlesi, P. yoelli, P. berghei, P. spp. chabaudi, P.gollinaceum, Leishmania donovani,