卵泡成熟及排卵是月经生理、生殖内分泌生理及受孕的基础 ,卵泡发育及成熟障碍可出现功能失调性子宫出血、月经稀发、闭经、不孕等无排卵性疾病。西医多采用激素促排卵 ,但存在许多问题。补肾固冲系列方是著名中医妇科专家顾小痴教授的验方之一 ,临床对治疗功能性子宫出血、不孕症、闭经等疾病有显著疗效。本研究是在补肾固冲系列方药治疗功能性子宫出血临床研究基础上 ,通过动物实验观察补肾固冲系列方对雄激素所致无排卵大鼠 (ASR)下丘脑—腺垂体—卵巢轴的影响 ,从细胞水平探讨补肾调经中药的调经和治疗无排卵疾病的作用环节和机理。为中药治疗无排卵疾病提供客观依据。本研究为河北省科技厅资助项目 (NO 96Z1113) ,现将其研究结果专题报告如下 Follicle maturation and ovulation are the basis of menstrual physiology, reproductive endocrine physiology, and conception. Follicle development and maturation disorders can occur with dysfunctional uterine bleeding, menstrual thinning, amenorrhea, infertility and other anovulatory diseases. Western medicine often uses hormones to promote ovulation, but there are many problems. The Bushen Guchong series is one of the prescriptions of Prof. Gu Xiaozhi, a famous gynecologist of traditional Chinese medicine, and has a significant clinical effect on the treatment of functional uterine bleeding, infertility, and amenorrhea. This study was based on the clinical study of Bushen Guchong series prescriptions for treating functional uterine bleeding. The effect of Bushenguchong series on the hypothalamus-adenohypophysis-ovary axis in androgen-induced anovulatory rats (ASR) was observed through animal experiments. , From the cellular level, explore the role and mechanism of regulating menstruation and treatment of anovulatory diseases in Bushen Tiaojing Traditional Chinese Medicine. It provides an objective basis for Chinese medicine treatment of anovulatory diseases. This study is a project funded by the Science and Technology Department of Hebei Province (NO 96Z1113). The special report on its research results is as follows: