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目的 探讨马鞭草醇提液 (ae Vo)对绒毛膜癌 JAR细胞株的影响。方法 JAR细胞株与人肝癌 SMMC- 772 1细胞株及人胚肺 2倍体成纤维细胞株 (2 BS)体外培养比较 ,应用溴化甲噻唑基四唑 (MTT)法、荧光法测得细胞相对生长曲线及增殖抑制率。结果 ae Vo对 JAR细胞有明显抑制作用 ,于加药后 4 8h,增殖抑制率为 (71.9± 4 .0 ) %及 (69.6± 2 .0 ) % ,MTT法及荧光法所测结果无明显差异 (P>0 .0 5 )。 ae Vo对 SMMC- 772 1细胞及 2 BS细胞无明显影响。结论 ae Vo具有抗绒癌作用 ,且作用具有特异性 ,有关机制需进一步研究
Objective To investigate the effect of verot (alcohol extract) on human choriocarcinoma JAR cell line. Methods Compared with in vitro culture of human hepatocellular carcinoma cell line SMMC-772 1 and human embryo lung 2-fibroblast cell line (2 BS), JAR cell line was treated with MTT assay and fluorescence assay Relative growth curve and proliferation inhibition rate. Results Ae Vo significantly inhibited the proliferation of JAR cells. The inhibition rate of proliferation was (71.9 ± 4 .0)% and (69.6 ± 2.0)% at 48 h after dosing. The results of MTT assay and fluorescence assay showed no significant difference Differences (P> 0.05). ae Vo had no significant effect on SMMC-772 1 cells and 2 BS cells. Conclusion ae Vo has anti-choriocarcinoma effect, and the role of specificity, the mechanism needs further study