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目的总结多囊卵巢综合征(PCOS)伴有黑棘皮病(AN)和不伴有该病的实验室检查指标的特点。方法将200209-200311在北京大学医学部第三医院妇科内分泌门诊就诊的163例多囊卵巢综合征患者根据是否伴有黑棘皮病分为两组,回顾性分析两组的临床资料,用放射免疫法测定卵泡刺激素、黄体生成素、血清泌乳素、雌二醇、睾酮、雄烯二酮。测定空腹血糖以及餐后30min、餐后60min的血糖值和胰岛素各个时点的值,计算葡萄糖和胰岛素的曲线下面积,计算胰岛素敏感系数、胰岛素抵抗指数。结果在性激素中只有血睾酮,伴AN组的患者高于不伴AN组的患者(P<0.05),其他两组间差异均无显著意义(P>0.05)。反映血糖及胰岛素水平的各项指标,两组间的差别均有显著意义(P<0.05),且伴AN组的水平均高于不伴AN组。结论伴有黑棘皮病的PCOS患者雄激素的改变以睾酮增高为主,而且伴有该病的患者更容易伴有糖代谢异常。
Objective To summarize the characteristics of polycystic ovary syndrome (PCOS) associated with acanthosis nigricans (AN) and laboratory tests not associated with the disease. Methods 200209-200311 in Peking University Third Hospital, Department of Gynecology and Endocrinology outpatient treatment of 163 patients with PCOS according to whether there is acanthosis nigricans divided into two groups, the clinical data of two groups were retrospectively analyzed by radioimmunoassay Determination of follicle stimulating hormone, luteinizing hormone, serum prolactin, estradiol, testosterone, androstenedione. Fasting blood glucose and 30min postprandial, 60min postprandial blood glucose and insulin at various time points were measured to calculate the area under the curve of glucose and insulin, insulin sensitivity index and insulin resistance index were calculated. Results Only the serum testosterone in sex hormones was higher in patients with AN than in those without AN (P <0.05). There was no significant difference between the other two groups (P> 0.05). The indicators reflecting blood glucose and insulin levels were significantly different between the two groups (P <0.05), and the levels in the AN group were higher than those in the non-AN group. Conclusions The changes of androgen in PCOS patients with acanthosis nigricans are mainly testosterone, and patients with this disease are more likely to have abnormal glucose metabolism.