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血小板激活因子(platelet-activating factor,PAF)是一种在炎症应答反应中发挥关键作用的双层磷脂分子。动物气管内滴注PAF可出现类似于间质性肺病的症状,本文目的是简要综述PAF在这类疾病中的作用。 一、PAF的一般特点 1972年,Benveniste发现IgE致敏的家兔嗜碱粒细胞能释放一种磷脂类分子,因其具有强烈刺激血小板聚集能力,故被命名为血小板激活因子(PAF)。1979年至1980年,几个研究小组证实PAF的化学结构式为1-O-烷基-2-乙酰基-Sn-甘油-3-磷酸胆碱。
Platelet-activating factor (PAF) is a bilayer phospholipid molecule that plays a key role in the inflammatory response. Intratracheal instillation of PAF in animals results in symptoms similar to those of interstitial lung disease. The purpose of this paper is to briefly review the role of PAF in these diseases. First, the general characteristics of PAF In 1972, Benveniste found that IgE sensitized rabbit basophil release of a phospholipid molecule, because of its strong ability to stimulate platelet aggregation, it was named platelet activating factor (PAF). From 1979 to 1980, several research groups confirmed that the chemical structure of PAF is 1-O-alkyl-2-acetyl-Sn-glycero-3-phosphocholine.