目的探讨妊娠期甲状腺疾病对新生儿甲状腺功能的影响。方法 95例妊娠期甲状腺疾病孕妇,均为单胎,根据血清促甲状腺素(thyroid stimulating hormone,TSH)水平分为TSH降低组31例、TSH升高组25例和TSH正常组39例,观察各组孕妇分娩的新生儿甲状腺功能异常发生率,检测并比较新生儿出生后3d及出生后1、3、6个月甲状腺激素水平和甲状腺自身抗体水平,对结果异常者进行干预,并观察干预效果。结果 TSH降低组和TSH升高组患者甲状腺疾病家族史比率(48.4%、48.0%)明显高于TSH正常组(38.5%)(P<0.05);新生儿出生3d内甲状腺功能异常发生率77.89%(74/95),其中甲状腺功能低下3例(3.16%),高TSH血症26例(27.37%),甲状腺自身抗体阳性者45例(47.37%),出生后1个月甲状腺自身抗体阳性者33例(34.74%),出生后3个月甲状腺自身抗体阳性者15例(15.79%),出生后6个月甲状腺自身抗体阳性者5例(5.26%);3组新生儿甲状腺功能低下发生率、高TSH血症发生率、出生后3d及出生后1、3、6个月甲状腺自身抗体阳性率比较差异无统计学意义(P>0.05);经治疗后无加重病例,1例甲状腺功能低下治疗无明显变化,余均明显好转。结论妊娠期甲状腺疾病患者分娩的新生儿在出生后第1~3个月有轻微TSH升高,多数新生儿TSH水平可恢复正常,无需干预。 Objective To investigate the influence of thyroid disease during pregnancy on the thyroid function of neonates. Methods Ninety-five pregnant women with thyroid disease during pregnancy were all singleton. According to the levels of serum thyroid stimulating hormone (TSH), 31 cases were divided into TSH reduction group, 25 TSH increase group and 39 TSH normal group. The incidence of abnormal thyroid function in newborns during delivery of the pregnant women was measured and compared. The level of thyroid hormone and the level of thyroid autoantibodies on the 3rd and 6th month after birth were detected and compared, and the abnormal results were observed. . Results The family history of thyroid disease (48.4%, 48.0%) was significantly higher in patients with TSH reduction and TSH elevation (38.5%) than those with TSH (P <0.05). The incidence of thyroid dysfunction was 77.89% (74/95), of which thyroid dysfunction in 3 cases (3.16%), 26 cases of hyper-TSH hyperlipidemia (27.37%), thyroid autoantibodies in 45 cases (47.37%), 1 month after birth thyroid autoantibodies were positive There were 33 cases (34.74%), 15 cases (15.79%) with thyroid autoantibodies positive at 3 months after birth and 5 cases (5.26%) with thyroid autoantibodies positive 6 months after birth. The incidence of hypothyroidism , The incidence of high TSH hyperlipidemia, postnatal 3d and 1,3,6 months after birth, the positive rate of thyroid autoantibodies was no significant difference (P> 0.05); after treatment without aggravating cases, 1 case of hypothyroidism No significant changes in treatment, I were significantly improved. Conclusions Newborns with gestational thyroid disease during delivery have a slight increase in TSH during the first 3 months after birth. Most newborns with TSH levels return to normal without intervention.